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LDH isoenzyme patterns in human gastric mucosa with precancerous changes
Author(s) -
CardaAbella P.,
PerezCuadrado S.,
MateJimenez J.
Publication year - 1978
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197808)42:2<490::aid-cncr2820420217>3.0.co;2-j
Subject(s) - medicine , gastric mucosa , precancerous condition , isozyme , cancer , pathology , gastroenterology , stomach , enzyme , biology , biochemistry
By using an original method of electrophoresis separation, the normal relative values of each one of the LDH isoenzymes in the gastric body and antral mucosa were determined. It has been shown in gastric tumors that there is a significant rise in the relative values of “type M” isoenzymes (iso‐LDH‐4–5). With intestinal metaplasia as well as gastritis, a significant elevation of the relative value of iso‐LDH‐5 has been demonstrated in the antral mucosa. In 6 benign gastric polyps we found a similar disturbance. This would confirm the known precancerous condition of these lesions. In the normal mucosa of subtotal gastrectomy specimens, 19 patients with antral cancer had 2 types of LDH isoenzyme patterns: one normal and the other with an increase in the relative proportion of “type M” isoenzymes. These LDH isoenzyme pattern shifts in the gastric mucosa could be an early sign of malignancy prior to the morphologic changes.