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Hodgkin's disease: Problems of staging
Author(s) -
Sweet Donald L.,
Kinnealey Ann,
Ultmann John E.
Publication year - 1978
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197808)42:2+<957::aid-cncr2820420719>3.0.co;2-d
Subject(s) - medicine , radiation therapy , stage (stratigraphy) , radiology , disease , laparotomy , chemotherapy , surgery , pathology , paleontology , biology
The preferred histopathological classification of Hodgkin's disease (HD) is that suggested by Lukes and Butler as modified at the Rye Symposium; the histologic subtypes are highly reproducible and correlate well with the anatomic sites of involvement, clinical stage, and survival. The accuracy of the bipedal lymphangiogram, 67 gallium scan, and ultrasonography in predicting abdominal involvement by HD is 90%, 50%, and 88%, respectively. Staging laparotomy remains the most accurate method of detecting intra‐abdominal disease and has added immensely to new concepts in the management of HD. These concepts suggest that patients with nodal disease limited to the celiac axis or upper para‐aortic areas (substage III 1 ) or pathologic stage (PS) III S+N‐ A, when treated with extended field radiotherapy alone have survival rates comparable to PS IIA patients. In contrast, patients in PS IIIA with lower abdominal nodal disease (substage III 2 ), regardless of splenic involvement, have a prognosis comparable to PS IV disease. Thus, there may only be two stages of HD, those curable with extended mantle or smaller radiotherapy fields alone, and those requiring chemotherapy with or without supplemental radiotherapy.