Premium
Normal and leukemic hemopoiesis compared
Author(s) -
McCulloch E. A.,
Buick R. N.,
Till J. E.
Publication year - 1978
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197808)42:2+<845::aid-cncr2820420706>3.0.co;2-x
Subject(s) - myelopoiesis , haematopoiesis , precursor cell , acute myeloblastic leukemia , lymphopoiesis , progenitor cell , immunology , leukemia , myeloid , biology , medicine , stem cell , cancer research , cell , microbiology and biotechnology , genetics
Using colony assays for human erythropoietic (BFU‐E, CFU‐E) and granulo‐poietic (CFU‐C) progenitors, normal and leukemic myelopoietic differentiation were compared; similar patterns were found in both. However, the origin of blast cells characteristic of the disease could not be established indicating the need for a direct approach to these cells. A colony assay for blast cells in acute myeloblastic leukemia is described. Blast cell colony‐formation is significantly correlated with blast cell number, and the colonies contain cells of blast like morphology without differentiation markers. It is proposed that this method, taken in conjunction with results from assays of myelopoiesis and lymphopoiesis, may provide a more complete picture of leukemic differentiation. It is anticipated that such a model will be useful in devising new therapies.