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Chemoimmunotherapy of small cell bronchogenic carcinoma
Author(s) -
Holoye Paul Y.,
Samuels Melvin L.,
Smith Terry,
Sinkovics Joseph G.
Publication year - 1978
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197807)42:1<34::aid-cncr2820420106>3.0.co;2-8
Subject(s) - chemoimmunotherapy , medicine , cyclophosphamide , vincristine , bronchogenic carcinoma , immunotherapy , regimen , oncology , chemotherapy , radiation therapy , active immunotherapy , carcinoma , surgery , cancer
Thirty‐one patients with small cell bronchogenic carcinoma were treated with a regimen of cyclophosphamide, Adriamycin and vincristine. Radiotherapy was given to patients with limited disease. Nonspecific immunotherapy consisting of BCG scarification was administered after each chemotherapy course. The results of treatment for this group were compared with those for a group of 45 patients treated similarly but with no immunotherapy. Therapeutic results, expressed in length of survival and rate of response, were similar. Myelosuppression was not modified by the addition of BCG scarification. This study showed no benefit from the use of such nonspecific immunotherapy.