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Incidence of meningeal involvement by rhabdomyosarcoma of the head and neck in children. A report of the intergroup rhabdomyosarcoma study (IRS)
Author(s) -
Tefft Melvin,
Fernandez Carlos,
Donaldson Milton,
Newton William,
Moon Thomas E.
Publication year - 1978
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197807)42:1<253::aid-cncr2820420139>3.0.co;2-j
Subject(s) - medicine , rhabdomyosarcoma , meninges , radiation therapy , incidence (geometry) , head and neck , complication , hyperfractionation , chemotherapy , surgery , radiology , sarcoma , nuclear medicine , pathology , dose fractionation , physics , optics
141 patients with embryonal rhabdomyosarcoma (RMS) of the head and neck are reviewed. 57/141 had lesions of para‐meningeal sites. 20/57 (35%) developed evidence of direct meningeal extension. 18/20 (90%) died of this complication. Radiation portals and doses were limited in 42% and 32%, respectively. All patients had chemotherapy for 6 weeks prior to radiation. The significance of the adequacy of radiation factors and the timing of chemotherapy are reviewed. Recommendations for managing these patients include earlier use of radiation and increased coverage of adjacent meninges by radiation including total craniospinal axis radiation when brain meningeal involvement exists.