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Glycosaminoglycan‐synthetic activity of pleomorphic adenoma, adenoid cystic carcinoma and nonneoplastic tubuloacinar cells of the salivary gland
Author(s) -
Takeuchi Jun,
Sobue Mitsuko,
Yoshida Masahiko,
Sato Emiko
Publication year - 1978
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197807)42:1<202::aid-cncr2820420133>3.0.co;2-8
Subject(s) - glycosaminoglycan , adenoid cystic carcinoma , pathology , salivary gland , pleomorphic adenoma , carcinoma , adenoid , adenoma , medicine , anatomy
Abstract An analysis was carried out on glycosaminoglycan produced in pleomorphic adenoma, adenoid cystic carcinoma, sialadenitis and normal tissue of the salivary gland. After incubation of the tissue segments in a medium containing 35 SO 4 , a radioautograph of the tissue section was made to observe the localization of 35 SO 4 incorporation, and 35 S‐labelled materials were purified from the tissues, and analyzed. High 35 S‐radioactivity was observed in the ductal cells of the inflammatory gland tissue and in the acinar cells of normal palatinal gland, but little radioactivity was observed in the interstitial components in these tissues, and the amount of 35 SO 4 incorporated in the tumor cells was also significant. Eighty to 90% of the 35 S‐radioactivity incorporated could be detected as 35 S‐glycosaminoglycans in all tissues except for the normal palatinal gland, which contained a large amount of 35 S‐sulfated glycoprotein. No significant differences in the synthetic activity of 35 S‐glycosaminoglycans and in their components were observed between nonneoplastic and neoplastic cells. These results suggest that glycosaminoglycan‐producing cells in pleomorphic adenoma as well as in adenoid cystic carcinoma are derived from the tubuloacinar cells of the salivary gland.