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Ultrastructure of primitive neuroectodermal neoplasms of the central nervous system
Author(s) -
Boesel Carl P.,
Suhan Joseph P.,
Bradel Edward J.
Publication year - 1978
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197807)42:1<194::aid-cncr2820420132>3.0.co;2-#
Subject(s) - ultrastructure , pathology , neuroepithelial cell , central nervous system , neoplasm , anatomy , medicine , neuroblastoma , biology , population , neuroscience , microbiology and biotechnology , stem cell , cell culture , neural stem cell , genetics , environmental health
The ultrastructure of one spinal and five cerebral neoplasms diagnosed by light microscopy as primitive neuroectodermal tumors supports a cell population consisting largely of poorly differentiated neuroepithelial cells. The most unique ultrastructural feature was the presence of annulate lamellae in four of the six cases. Glial cells in the neoplasm were not unequivocally of neoplastic origin and were possible reactive. There was no evidence of neuroblastic or neuronal elements, although there was frequently focal early neuroblastic differentiation by light microscopy. Although we have seen neoplasms which are clearly neuroblastic, these particular tumors are not purely neuroblastic and should not be classified as neuroblastomas.