Premium
Effects of ultraviolet light on nude mice. Cutaneous carcino genesis and possible leukemo genesis
Author(s) -
Eaton Gordon J.,
Custer R. Philip,
Crane A. Reynolds
Publication year - 1978
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197807)42:1<182::aid-cncr2820420130>3.0.co;2-c
Subject(s) - hairless , leukemia , medicine , cancer research , nude mouse , pathology , ultraviolet light , cell , basal cell , immunology , biology , cancer , chemistry , genetics , photochemistry
Squamous cell carcinomas were induced by ultraviolet irradiation in the skin of all T‐cell deficient nude mice rendered sufficiently long‐lived by reconstitution with syngeneic splenic or thymic cells. All homozygous hairless mice similarly exposed developed squamous cell carcinomas. Striking granulocytic proliferation was provoked in one hairless and in five reconstituted nude mice; two of the latter were interpreted as having true granulocytic leukemia.