Premium
Bone marrow acid phosphatase by radioimmunoassay
Author(s) -
Belville William D.,
Cox H. David,
Mahan Donald E.,
Olmert J. Phillip,
Mittemeyer Bernhard T.,
Bruce Andrew W.
Publication year - 1978
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197806)41:6<2286::aid-cncr2820410629>3.0.co;2-2
Subject(s) - radioimmunoassay , prostatic acid phosphatase , medicine , bone marrow , acid phosphatase , carcinoma , hyperplasia , prostate , pathology , alkaline phosphatase , stage (stratigraphy) , cancer , enzyme , chemistry , biochemistry , biology , paleontology
Abstract A double‐antibody radioimmunoassay was developed and utilized to measure prostatic acid phosphatase in bone marrow aspirates. One hundred‐eighteen patients with carcinoma of the prostate in various clinical stages, and fifty with benign prostatic hyperplasia were studied. In patients with carcinoma, levels of prostatic acid phosphatase in bone marrow aspirates were found to correlate well with increasing clinical stage of the disease. Determination of bone marrow prostatic acid phosphatase by radioimmunoassay may be a valuable adjunct to clinicopathologic staging of prostatic carcinoma.