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Halothane, surgery, immunosuppression and artificial pulmonary metastases
Author(s) -
Lundy Joel,
Lovett Edmund J.,
Hamilton Susan,
Conran Philip
Publication year - 1978
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197803)41:3<827::aid-cncr2820410307>3.0.co;2-#
Subject(s) - medicine , immunosuppression , halothane , surgery , anesthesia
C57B1/6 mice were given intravenous tumor cells on day O. Mice were then given either a brief exposure to halothane anesthesia or given halothane and then underwent a hind limb amputation. Immune testing was done at varying time intervals and correlated with the development of artificial pulmonary metastases. The effects of a single 15 minute exposure to halothane on the immune system are probably short‐lived and no effect on cell‐mediated cytotoxicity was seen on day 7, nor was an increase in pulmonary metastases observed. However, when anesthesia was combined with surgery, cell‐mediated cytotoxicity was impaired and an increase in pulmonary metastases was seen. The use of thiabendazole (TBZ), an nonspecific immunopotentiator, in the perioperative period restored the cell‐mediated cytotoxic response and resulted in a significant decrease in pulmonary metastases.