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Production of several substances by medullary carcinoma of the thyroid
Author(s) -
Iwanaga Takeshi,
Koyama Hiroki,
Uchiyama Setsuo,
Takahashi Yoshikazu,
Nakano Shunnichi,
Itoh Tadao,
Horai Takeshi,
Wada Akira,
Tateishi Ryuhei
Publication year - 1978
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197803)41:3<1106::aid-cncr2820410345>3.0.co;2-8
Subject(s) - medicine , calcitonin , medullary cavity , medullary carcinoma , thyroid , hormone , thyroid carcinoma , pathology , endocrinology , gastrin , carcinoma , thyroid hormones , secretion
Two patients with the typical morphology of medullary carcinoma of the thyroid are reported. Biochemical analysis of the tumor tissue demonstrated the presence of calcitonin, ACTH and MSH, although symptoms referable to these hormones were hardly manifested. Serum CEA levels were elevated and CEA immunofluorescences in the tumor cells were positive. Moreover, in one patient, serotonin concentration was raised in the tumor tissue, and gastrin level was also elevated in the peripheral blood. These results suggest that the tumors may produce several substances.