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Effect of radiation on cell‐mediated cytotoxicity and lymphocyte subpopulations in patients with ovarian carcinoma
Author(s) -
Kohorn Ernest I.,
Mitchell Malcolm S.,
Dwyer John M.,
Knowlton Arthur H.,
KleinAngerer Sigrid
Publication year - 1978
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197803)41:3<1040::aid-cncr2820410336>3.0.co;2-n
Subject(s) - medicine , ovarian cancer , stage (stratigraphy) , ovarian carcinoma , radiation therapy , lymphocyte , cytotoxicity , depression (economics) , oncology , chemotherapy , carcinoma , cancer , gastroenterology , immunology , biology , paleontology , biochemistry , macroeconomics , economics , in vitro
Lymphocyte subpopulations and cell‐mediated cytotoxicity (CMI) were studied during radiation therapy in 16 patients with ovarian carcinoma. The total lymphocyte count became depressed in all patients. The depression was more marked among T cells, while the proportion of B cells remained unaffected. In patients with Stage I and II ovarian cancer, CMI was depressed significantly by radiotherapy after 7 days of treatment, remained low at 14 days but recovered despite continuation of radiation. This depression of CMI occurred at a delivered dose of 1,000 rads with subsequent recovery. Patients with Stage III ovarian cancer given pelvic and abdominal radiation were found to have no consistent depression of CMI, a finding similar to that in Stage III ovarian carcinoma patients given chemotherapy.