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Malignant transformation of esophageal columnar epithelium
Author(s) -
Berenson M. M.,
Riddell R. H.,
Skinner D. B.,
Freston J. W.
Publication year - 1978
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197802)41:2<554::aid-cncr2820410223>3.0.co;2-v
Subject(s) - esophagus , medicine , epithelium , adenocarcinoma , pathology , malignant transformation , carcinoma in situ , carcinoma , columnar cell , precancerous condition , cancer , anatomy
This report describes two patients with esophageal columnar epithelium (Barrett's esophagus) in which microinvasive adenocarcinoma developed. Case 1 had multiple foci of carcinoma in situ contiguous with epithelium resembling gastric and intestinal mucosa. Case 2 had signet‐ring type adenocarcinoma. Surveillance for malignant transformation in columnar esophageal epithelium should be routinely performed, and because of its focal nature, multiple biopsies and cytologic examination should be carried out. The presence of carcinoma in situ should lead to consideration of excision of the affected esophagus.