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Contribution of angiography to the diagnosis, staging and assessment of radiation and chemotherapy of solid abdominal malignancies in children
Author(s) -
Rösch Josef,
Neerhout Robert C.,
Campbell John R.,
Stevens Kenneth R.
Publication year - 1978
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197802)41:2<468::aid-cncr2820410214>3.0.co;2-j
Subject(s) - medicine , hepatoblastoma , wilms' tumor , neuroblastoma , chemotherapy , angiography , radiology , radiation therapy , stage (stratigraphy) , cancer , pathology , paleontology , biology , genetics , cell culture
Sequential angiographic studies were done in six children to stage and assess the results of radiation and/or chemotherapy of solid abdominal malignancies: one bilateral Wilms' tumor, two neuroblastomas, two hepatoblastomas and one hepatocarcinoma. Angiography was of value in demonstrating the tumor, its location, extent and vascular characteristics, as well as its regression and recurrence. Wilms' tumor and neuroblastoma responded well to radiation and chemotherapy with substantial decrease in tumor size and regression or disappearance of tumor neovasculature. Resected tumors revealed this to be due to tumor necrosis, hemorrhage and/or cystic degeneration. Hepatoblastoma and hepatocarcinoma did not respond as well to chemotherapy, with only mild decrease in size and neovasculature of the tumor.