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Oral high‐dose methotrexate with citrovorum factor rescue in metastatic squamous cell carcinoma of the lung
Author(s) -
Tornyos Karl,
Faust Hiltrud
Publication year - 1978
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197802)41:2<400::aid-cncr2820410204>3.0.co;2-d
Subject(s) - medicine , methotrexate , squamous cell cancer , regimen , basal cell , oncology , lung , epidermoid carcinoma , gastroenterology , squamous cell carcinoma of the lung , cancer , lung cancer , surgery
Thirteen patients with metastatic squamous cell cancer of the lung were treated, in a nonrandomized study, with an oral high‐dose methotrexate and citrovorum factor rescue regimen. There was some response and/or stabilization of disease for at least three months in six (46%) of 13 cases. The median survival time of the study group was double (365 vs. 180 days) that of a retrospectively matched control group. This suggests a possible therapeutic effect of this treatment program in metastatic squamous cell cancer of the lung.