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Combination chemotherapy of metastatic breast cancer with vincristine, adriamycin and prednisolone
Author(s) -
Russell J. A.,
Baker J. W.,
Dady P. J.,
Ford H. T.,
Gazet J. C.,
McKinna J. A.,
Nash A. G.,
Powles T. J.
Publication year - 1978
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197802)41:2<396::aid-cncr2820410203>3.0.co;2-t
Subject(s) - medicine , prednisolone , vincristine , breast cancer , metastatic breast cancer , chemotherapy , oncology , combination chemotherapy , cancer , doxorubicin , lung cancer , cyclophosphamide
Fifty patients with metastatic breast cancer were treated with a combination of vincristine, Adriamycin and prednisolone (VAP) at four weekly intervals. Response rates of 78% for soft tissue disease, 66% for parenchymal lung disease, 67% for liver disease, and 64% for pleural effusions were seen. Only 26% of patients with bone metastases showed an objective response. These figures are as good as any previously reported for chemotherapy of breast cancer.