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Hodgkin's disease, lymphocyte depletion Type. A clinicopathologic study of 39 patients
Author(s) -
Bearman Robert M.,
Pangalis Gerassimos A.,
Rappaport Henry
Publication year - 1978
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197801)41:1<293::aid-cncr2820410141>3.0.co;2-d
Subject(s) - medicine , splenectomy , lymph node , lymphocytopenia , bone marrow , autopsy , disease , pathology , spleen , surgery , gastroenterology , lymphocyte
A clinicopathologic analysis of 39 patients with Hodgkin's disease of the lymphocyte depletion type (LDHD) confirmed that this is the most aggressive form of the disease, but that it does not necessarily have a rapidly fatal course. The median survival in our series was 25.1 months; eight patients (21%) survived four years or longer. There were no clinical or survival differences between the reticular and the diffuse fibrosis subtypes. The majority (74%) of the patients were males. The median age was 48 years. Most patients in both groups presented with constitutional symptoms, peripheral lymph node enlargement and splenic or hepatic enlargement, or both. The diagnosis was established on a peripheral lymph node in 81% of the cases. Mediastinal involvement was present in 36% of the cases and was a favorable prognostic feature. Anemia and lymphocytopenia were common at presentation. Autopsy in 14 patients revealed involvement of lymph nodes in every case, liver and bone marrow in 13 cases and the spleen in all (11) cases which had not undergone prior splenectomy as part of a staging laparotomy. There was a high incidence of usually noncontiguous lung involvement. Our data indicate that despite the advanced stage of disease at presentation patients with LDHD can be salvaged with chemotherapy. They do not suggest that LDHD represents a distinct clini‐copathologic entity.