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Chromosomes and causation of human cancer and leukemia. XXIX.Further studies on karyotypic progression in CML
Author(s) -
Sonta ShinIchi,
Sandberg Avery A.
Publication year - 1978
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197801)41:1<153::aid-cncr2820410124>3.0.co;2-d
Subject(s) - chromosomal translocation , karyotype , myelocytic leukemia , cancer , cytogenetics , biology , medicine , genetics , leukemia , chromosome , gene
Fifty‐seven Ph 1 ‐positive cases of chronic myelocytic leukemia (CML) were analyzed with chromosomal banding techniques and their karyotypic progression followed. These cases included 1 without evidence of a Ph 1 ‐translocation and 1 new patient with a complex Ph 1 ‐translocation involving chromosomes #9, #17 and #22. Of the 57 patients, 28 had the Ph 1 as the only karyotypic anomaly, whereas the remaining 29 cases developed and/or were associated with chromosomal changes usually of a hyperdiploid nature, particularly in the blastic phase, in addition to the Ph 1 . Even though the additional karyotypic changes frequently included chromosomes #8, #17, #19 and #21, a large number of others was also involved, although less often. The series included 3 cases with different types of translocations unrelated to the Ph 1 . The cytogenetic observations have been correlated with some of the clinical parameters. The survival of the patients was evaluated in relation to the karyotypic findings, indicating that the chromosomal changes may not play as important a role in the prognostic and progressive aspects of Ph 1 ‐positive CML as that of other as yet undetermined factors.