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The reversible behavior of locally invasive endometrial carcinoma in a chromosomally mosaic (45,x/46,xr(x)) young woman treated with clomid®
Author(s) -
Moukhtar M.,
Aleem F. A.,
Hung H. C.,
Sommers S. C.,
Klinger H. P.,
Romney S. L.
Publication year - 1977
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197712)40:6<2957::aid-cncr2820400631>3.0.co;2-m
Subject(s) - medicine , endometrium , endometrial cancer , carcinoma , ovulation , endometrial hyperplasia , endocrinology , cancer , gynecology , hormone
A 22 year‐old phenotypic female with a 45,x/46,x, r(x) mosaic complement had anovulatory cycles, histologically normal ovaries, and atypical endometrial hyperplasia which, when clinically followed by repeated biopsies, was found to progress to locally invasive endometrial carcinoma. This was successfully managed by the induction of ovulation with Clomid®, which resulted in conversion of the endometrium to a normal secretory pattern for two subsequent years. Cancer 40:2957‐2966, 1977.