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Comparison of oncophilic radiopharmaceuticals, *I‐fibrinogen, 67 Ga‐ citrate, 111 In‐bleomycin, and *I‐bleomycin in tumor‐bearing mice
Author(s) -
Denardo Gerald L.,
Krohn Kenneth A.,
Denardo Sally J.
Publication year - 1977
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197712)40:6<2923::aid-cncr2820400625>3.0.co;2-q
Subject(s) - bleomycin , medicine , in vivo , clearance , fibrinogen , pharmacokinetics , pharmacology , chemotherapy , urology , biology , microbiology and biotechnology
The pharmacokinetics of 67 Ga‐citrate, 111 ‐bleomycin, *I‐bleomycin, and *I‐fibrinogen were compared in a murine KHJJ tumor model in order to assess their relative potential as agents for in vivo detection of cancer. Although all four agents have been reported to be clinically efficacious, in this tumor model, *I‐fibrinogen and 67 Ga‐citrate had the greatest tumor accumulation with maximum concentrations of 11.7% and 10.5% respectively. However, both these radiopharmaceuticals cleared slowly from the blood and animal. The maximum tumor concentrations of 111 In‐bleomycin and *I‐bleomycin were 2.9% and 2.6% respectively, but *I‐bleomycin had the advantage of rapid clearance from the blood and animal. 67 Ga‐citrate did not achieve its maximum tumor concentration until 24 hours after administration, whereas the other radiopharmaceuticals achieved maximum tumor concentration within several hours of administration. From these observations 123 I‐bleomycin seems to deserve clinical trials in patients. 123 I‐fibrinogen appears to have significant oncophilic potential if its clearance from the animal can be accelerated without altering its accumulation in the tumor. Cancer 40:2923‐2929, 1977.