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High dose methotrexate with citrovorum factor in adult resistant lymphoma
Author(s) -
Turman Steven,
Coleman Morton,
Silver Richard T.,
Pasmantier Mark
Publication year - 1977
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197712)40:6<2823::aid-cncr2820400612>3.0.co;2-2
Subject(s) - medicine , methotrexate , lymphoma , oncology
Seven adult patients with advanced lymphoma, resistant to vincristine, prednisone, alkylating agents and Adriamycin were treated with “high dose” methotrexate and citrovorum factor rescue. Therapy consisted of 4 to 6‐hour infusions of methotrexate (5‐100 mg/kg) every 1 to 2 weeks with citrovorum rescue initiated 2 to 12 hours after termination of the infusion. Objective responses were obtained in three patients but these were short lived. Mucosal and hematologic toxicity occurred when repeat courses of therapy were administered. The results suggest that high dose methotrexate may be effective therapy in lymphoma, particularly if citrovorum factor rescue is used early and in adequate dosage. Cancer 40:2823‐2828, 1977.