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Human leukemic “null” cell line (NALL‐1)
Author(s) -
Hiraki Shunkichi,
Miyoshi Isao,
Kubonishi Ichiro,
Matsuda Yuzo,
Nakayama Takashi,
Kishimoto Hirofumi,
Masuji Hiroshi
Publication year - 1977
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197711)40:5<2131::aid-cncr2820400523>3.0.co;2-v
Subject(s) - medicine , cell culture , human cell , computational biology , cancer research , genetics , biology
A human lymphoblast cell line, NALL‐1, was established from the peripheral blood of a patient with acute lymphoblastic leukemia (ALL). NALL‐1 cells had neither properties of T and B cells nor Epstein‐Barr virus (EBV). Many characteristics of the NALL‐1 line were distinct from those of numerous EBV‐positive lymphoblastoid cell lines previously reported. NALL‐1 cells are considered to have originated from the donor's leukemic cells on the basis of their cytogenetic, morphologic and functional features. The NALL‐1 line is the first human leukemic “null” cell line derived from ALL. The significance of this cell line is discussed.