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Chemoimmunotherapy for canine lymphosarcoma
Author(s) -
Crow Steven E.,
Theilen Gordon H.,
Benjamini Eliezer,
Torten Michael,
Henness Anita M.,
Buhles William C.
Publication year - 1977
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197711)40:5<2102::aid-cncr2820400519>3.0.co;2-e
Subject(s) - medicine , chemoimmunotherapy , cancer , immunotherapy
Thirty‐two dogs with naturally occurring multicentric lymphosarcoma were randomly assigned to one of two treatment groups. One half of the animals received combination chemotherapy plus vitamin injections (controls) while the other half received identical chemotherapy plus injections of chemically‐modified tumor cell extract in Freund's complete adjuvant (vaccinates). Clinical staging revealed no bias between groups but showed that prognosis could be closely correlated with the severity of disease at initial presentation. Twenty dogs (62%), including 11 vaccinates and 9 controls, responded favorably to chemotherapy and were evaluated for length of first remission and total survival time. Both parameters were significantly longer in vaccinated dogs than in controls. These data suggest that immunological stimulation may be a helpful adjunct to conventional therapy in selected types of cancer when immunological principles are observed.