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Clinical course and management of accidental adriamycin extravasation
Author(s) -
Reilly James J.,
Neifeld James P.,
Rosenberg Steven A.
Publication year - 1977
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197711)40:5<2053::aid-cncr2820400509>3.0.co;2-a
Subject(s) - medicine , extravasation , accidental , course (navigation) , intensive care medicine , pathology , acoustics , astronomy , physics
Adriamycin infiltration into subcutaneous tissues during intravenous administration results in an intense inflammatory response, which may progress to full‐thickness skin loss and irreversible damage to underlying tendons and neuro‐vascular structures. An analysis of 10 patients seen with Adriamycin infiltration indicated that healing of ulcerated lesions is often prolonged and associated with significant morbidity. Seven patients suffered skin ulcerations and three had severe functional impairment due to joint contractures. Adriamycin should not be infused near joints if possible. Surgical excision of ulcers is advocated if healing is prolonged. Proper local therapy, as well as early attention to proper splinting and physical therapy, can help reduce ultimate functional disability.