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Nitrosamines and nitrosamides in the etiology of gastrointestinal cancer
Author(s) -
Lijinsky William
Publication year - 1977
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197711)40:5+<2446::aid-cncr2820400909>3.0.co;2-q
Subject(s) - in vivo , nitroso compounds , medicine , nitrite , etiology , stomach , colorectal cancer , cancer , gastroenterology , nitroso , gastrointestinal cancer , biochemistry , medicinal chemistry , chemistry , organic chemistry , biology , microbiology and biotechnology , nitrate
It has been amply demonstrated that N‐nitroso compounds are formed by interaction of nitrite with secondary and tertiary amino compounds, and that this reaction can occur in vivo as well as in food processed with nitrite. The favored site of reaction in vivo is the stomach. It is likely that N‐nitroso compounds formed in this way, especially nitrosamides, could reach the colon and contribute to the induction of colon tumors.