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Inhibitors of colon carcinogenesis
Author(s) -
Wattenberg Lee W.,
Lam Luke K. T.,
Fladmoe Alan V.,
Borchert Peter
Publication year - 1977
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197711)40:5+<2432::aid-cncr2820400907>3.0.co;2-8
Subject(s) - disulfiram , carcinogen , azoxymethane , 1,2 dimethylhydrazine , medicine , pharmacology , dimethylhydrazine , chemistry , carcinogenesis , biochemistry , colorectal cancer , cancer
Disulfiram (tetraethylthiuram disulfide, Antabuse) and sodium diethyldithio‐carbamate, when added to the diet, inhibit 1,2‐dimethylhydrazine (DMH)‐induced neoplasia of the large bowel in female CF 1 mice. Ethylene bis(dithiocarbamato)manganese (Maneb) and bis(ethylxanthogen), two pesticides with structural similarities to disulfiram, produce comparable inhibition of DMH. In other work, disulfiram was found to inhibit the carcinogenic effect of azoxymethane (AOM) on the large bowel. Under comparable conditions the inhibition of AOM was considerably less than that obtained with DMH as the carcinogen. The data suggest that disulfiram inhibits DMH metabolism at more than one oxidative step.