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The effect of surgical resection of experimental “primary” adenocarcinoma of the colon on survival and incidence of metastases
Author(s) -
McCall Dolly C.,
Lawrence Roberta,
Goldenberg Ira S.
Publication year - 1977
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197710)40:4<1492::aid-cncr2820400420>3.0.co;2-u
Subject(s) - medicine , adenocarcinoma , colonic carcinoma , colorectal cancer , incidence (geometry) , primary tumor , surgical resection , resection , adjuvant therapy , colorectal adenocarcinoma , cancer , oncology , carcinoma , metastasis , surgery , pathology , gastroenterology , physics , optics
The effect of surgical resection of “primary” tumors classified by size at the time of resection has been studied in two tumor cell lines derived from di‐methylhydrazine‐induced colonic neoplasms in the Buffalo strain rat. Surgical treatment of colon cancer in the rat yields results similar to those for human carcinoma. Some of the smallest tumors resected were associated with metastases and this finding suggests a need for effective postoperative adjuvant therapy. The incidence of metastases and the size of the tumor were inversely related to survival, e.g., the smaller the tumor or the sooner the excision, the greater the survival of the animal. The operated animal model studied here could prove to be very useful for evaluating various forms of systemic therapy for the control of micrometastases associated with colonic neoplasms.