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Atypical fibroxanthoma of the skin. An ultrastructural study of two cases
Author(s) -
AlguacilGarcia Antonio,
Unni Krishnan K.,
Goellner John R.,
Winkelmann R. K.
Publication year - 1977
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197710)40:4<1471::aid-cncr2820400418>3.0.co;2-c
Subject(s) - atypical fibroxanthoma , medicine , dermatology , pathology , ultrastructure , immunohistochemistry
The ultrastructure of two atypical fibroxanthomas of the skin was studied. The first lesion was a spindle cell tumor on light microscopy, which electron micros copy revealed was composed of undifferentiated mesenchymal cells. The second lesion had a highly pleomorphic appearance on both light and electron microscopy. It was formed by atypical histiocytic cells and abundant “typical” Langerhans cells. The second lesion was considered to be a proliferation either of atypical Langerhans cells or of histiocytes related to Langerhans cells. Thus, atypical fibroxanthoma of skin may not be a homogeneous entity but could be a group of mesenchymal proliferative lesions in a similar clinical setting.