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Carcinogenic action of anticancer drugs with special reference to immunosuppression
Author(s) -
Schmähl D.
Publication year - 1977
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197710)40:4+<1927::aid-cncr2820400825>3.0.co;2-s
Subject(s) - carcinogen , immunosuppression , carcinogenesis , medicine , immune system , cancer research , pharmacology , immunology , cancer , toxicology , biology , biochemistry
Some anticancer drugs, especially alkylating agents, have under certain conditions shown a carcinogenic effect in animals, as well as in man. This carcinogenic effect is not due to the immunosuppressive properties of these substances but is directly related to their physicochemical properties. In extensive experimental studies with rats, a connection between the immune status of the host organism and the chemical carcinogenesis could not be proved.