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Antibody responses in normal infants and in infants receiving chemotherapy for congenital neuroblastoma
Author(s) -
Orgel H. Alice,
Hamburger Robert N.,
Mendelson Louis M.,
Miller J. Randall,
Kung Faith H.
Publication year - 1977
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197709)40:3<994::aid-cncr2820400305>3.0.co;2-5
Subject(s) - medicine , neuroblastoma , chemotherapy , antibody , immunization , tetanus , pediatrics , immunology , vaccination , genetics , biology , cell culture
Three infants with congenital neuroblastoma received a primary series of diptheria‐pertassis‐tetanus (DPT) immunizations during and after courses of chemotherapy with immunosuppressive medications. Serum IgG, IgA and IgM levels and antidiphtheria and antitetanus antibody responses were measured and compared with those of normal infants of similar age. Protective levels of antibody were achieved by the study patients as well as by the control group. These results support the view that children with malignancies who are receiving chemotherapy should not be denied immunization with inactivated vaccines.