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Lymphoid blastic crisis at the onset of chronic granulocytic leukemia. Report of two cases
Author(s) -
Mauri Carlo,
Torelli Umberto,
Prisco Ubaldo Di,
Silingardi Vittorio,
Artusi Tullio,
Emilia Giovanni
Publication year - 1977
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197708)40:2<865::aid-cncr2820400240>3.0.co;2-q
Subject(s) - chronic granulocytic leukemia , medicine , philadelphia chromosome , leukemia , bone marrow , chronic lymphatic leukemia , cancer , lymphoblastic leukemia , alkaline phosphatase , chronic leukemia , precursor cell , immunology , lymphatic system , pathology , acute leukemia , cell , genetics , chromosomal translocation , biology , enzyme , gene , biochemistry
Two patients with a typical hematologic pattern of acute lymphatic leukemia were brought into complete remission by treatment. A few weeks later they developed a typical peripheral and bone marrow pattern of chronic granulocytic leukemia, with Philadelphia chromosome and very low leukocyte alkaline phosphatase. These cases, along with other findings recently reported in the literature, support the possibility of a previously unrecognized relationship between lymphoblastic cell populations and chronic granulocytic leukemia. Cancer 40:865–870, 1977.