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Viral oncolysate in the management of malignant melanoma. I. Preparation of the oncolysate and measurement of immunologic responses
Author(s) -
Cassel William A.,
Murray Douglas R.,
Torbin Arlene H.,
Olkowski Zbigniew L.,
Moore Melanie E.
Publication year - 1977
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197708)40:2<672::aid-cncr2820400213>3.0.co;2-y
Subject(s) - melanoma , medicine , newcastle disease , antibody , cancer , malignant disease , immunology , virus , cancer research
Primary explants of human malignant melanoma were utilized in the preparation of oncolysates by Newcastle disease virus. The concentrated lysate, administered parenterally, was employed in an effort to augment antitumor immunologic responses in patients with metastatic melanoma. Observed cellular changes suggested a benefit, but humoral antibody measurements were not impressive. Cancer 40:672–679, 1977.