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Soluble membrane antigens of brain tumors. I. Controlled testing for cell‐mediated immune responses in a long surviving glioblastoma multiforme patient
Author(s) -
Hitchcock M. H.,
Hollinshead Ariel C.,
Chretien P.,
Rizzoli H. V.
Publication year - 1977
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197708)40:2<660::aid-cncr2820400211>3.0.co;2-a
Subject(s) - glioblastoma , medicine , immune system , antigen , brain tumor , cell , cancer research , pathology , immunology , biology , genetics
A patient with glioblastoma multiforme survived 18 years after diagnosis and underwent 20 operations for extracranial metastasis. An immunologic survey of the patient was made over a 1‐year‐period using in vitro tests of lymphocyte responsiveness and skin tests with control and tumor antigens isolated from autologous and allogenic brain cell membranes. Two tissue‐associated soluble cell membrane antigens also present in normal white matter, and two tumorassociated antigens (TAA) produce cell‐mediated immune responses in patients with brain tumors. One of these tumor‐associated antigens predominates in meningioma cells. In addition some low molecular weight components appeared, which seemed to be unique for the glioblastoma cells from the longsurviving patient. Cancer 40:660–666, 1977.