Premium
Oat cell carcinoma of the lung. Combination treatment with radiotherapy and cyclophosphamide, adriamycin, vincristine, and methotrexate
Author(s) -
Wittes Robert E.,
Hopfan Seymour,
Hilaris Basil,
Golbey Robert B.,
Melamed Myron,
Martini Nael
Publication year - 1977
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197708)40:2<653::aid-cncr2820400210>3.0.co;2-5
Subject(s) - medicine , vincristine , cyclophosphamide , radiation therapy , chemotherapy , surgery , regimen , chemotherapy regimen , gastroenterology
Patients with oat cell carcinoma of the lung and no prior chemotherapy were treated with a regimen composed of cyclophosphamide 1000 mg/m 2 intravenously (i.v.) day 1, Adriamycin 30 mg/m 2 i.v. day 1, vincristine 1.4 mg/m 2 i.v. day 1, and methotrexate 30 mg/m 2 i.v. day 22. Treatments were recycled every month. For most patients with locoregional involvement, radiation therapy (60‐Co 3000 R in 10 treatments to primary, mediastinum, and clinically involved cervical nodes) was given before chemotherapy, if the patient had not received radiation prior to the referral. Of 29 patients evaluable for an antitumor response to combined therapy, 83% showed complete or partial (greater than 50%) regression of tumor; the median duration of response was 8 months (range 1–16 months). Of 15 patients treated initially with chemotherapy, 80% had complete or partial regression of tumor. Median survival from start of therapy was 12 months for those with limited disease at presentation and 8 months for those presenting with disseminated disease. Subsequent progression of disease occurred in all major organ sites, even including lung and mediastinum which had been sites of prior radiotherapy. Dose‐limiting toxicities included white blood cell counts <3000 in 85%, with five cases of sepsis and two deaths, platelet counts <100,000 in 12%, and significant esophagitis in eight patients who received radiation therapy and chemotherapy in close temporal relation. Cancer 40:653–659, 1977.