Premium
Combination chemotherapy of germ cell tumors of the testis with vincristine, adriamycin, cyclophosphamide, actinomycin D and medroxyprogesterone acetate
Author(s) -
Klepp Olbjørn,
Klepp Ragnhild,
Høst Herman,
Asbjørnsen Gunnar,
Talle Kristian,
Stenwig Anna Elisabeth
Publication year - 1977
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197708)40:2<638::aid-cncr2820400208>3.0.co;2-6
Subject(s) - medicine , medroxyprogesterone acetate , vincristine , cyclophosphamide , leukopenia , chemotherapy , medroxyprogesterone , melphalan , stomatitis , oncology , combination chemotherapy , toxicity , gastroenterology , germ cell tumors , hormone
Forty‐three patients with disseminated germ cell cancer were treated with a combination of vincristine, Adriamycin, cyclophosphamide, actinomycin‐D, and medroxyprogesterone acetate. All the 43 patients were considered evaluable for response. Thirty‐one patients (72%) achieved a complete or partial remission and 14 (32.5%) achieved a complete remission. The patients who attained an objective response obtained a significant prolongation of life compared with the nonresponders (median survival 55 vs. 23 weeks). Responses were seen in all histologic categories and most frequently in patients with metastases confined to the lungs. The major side effects were leukopenia and stomatitis. There were no deaths related to toxicity of the chemotherapy. Cancer 40:638–646, 1977.