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Cellular immunity to herpes simplex virus in man. VII. K‐cell activity to HSV1 infected target cells in disease
Author(s) -
Russell A. S.,
Essery G.
Publication year - 1977
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197707)40:1<42::aid-cncr2820400109>3.0.co;2-f
Subject(s) - antibody dependent cell mediated cytotoxicity , herpes simplex virus , cytotoxic t cell , immunology , medicine , virus , immunity , immune system , antibody , virology , cellular immunity , disease , biology , in vitro , monoclonal antibody , pathology , biochemistry
Herpes simplex virus‐infected target cells sensitised with antiviral antibody can be lysed by non‐immune human lymphocytes (K‐cells). This antibody dependent cell mediated immunity (ADCC) is a very efficient technique for destroying foreign target cells and may play a role in maintaining the localization of recurrent herpetic infections. We have used 51 Cr labelled herpes virus infected target cells to examine the K‐cell activity of peripheral blood lymphocytes in patients who have either malignant reticuloendothelial diseases or who are receiving cytotoxic and steroid therapy for other reasons. K‐cell activity was generally within the normal range in such patients and was surprisingly stable despite the occasional use of relatively large doses of cytotoxic agents. It is unlikely, therefore, that a defect in ADCC is responsible for the dissemination of herpes virus infections that may be seen in association with the above drugs and diseases. Cancer 40:42–45, 1977.