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Expression of histocompatibility (HLA) antigens on tumor cells and normal cells from patients with melanoma
Author(s) -
Pellegrino M. A.,
Ferrone S.,
Reisfeld R. A.,
Irie R. F.,
Golub S. H.
Publication year - 1977
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197707)40:1<36::aid-cncr2820400108>3.0.co;2-7
Subject(s) - medicine , histocompatibility , human leukocyte antigen , melanoma , antigen , immunology , major histocompatibility complex , minor histocompatibility antigen , pan t antigens , cancer research , antibody , monoclonal antibody
The expression of HLA antigens and β 2 ‐microglobulin (β 2 ‐μ) on cultured melanoma cells originated from 11 patients has been quantitated and compared with that on fibroblasts and cultured human lymphoid cells originated from the same patients. No qualitative or quantitative difference was detected with the exception of one melanoma line. HLA antigens were also quantitated in sera from melanoma patients: two sera reacted with anti‐HLA‐B7 antibodies although this specificity was not expressed on lymphocytes from whom the sera were obtained. A technique to quantitate HLA antigens on cells developed in the course of this study is described. Cancer 40:36–41, 1977.