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Malignant giant cell tumor of soft parts. An ultrastructural study of four cases
Author(s) -
AlguacilGarcia Antonio,
Unni Krishnan K.,
Goellner John R.
Publication year - 1977
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197707)40:1<244::aid-cncr2820400137>3.0.co;2-#
Subject(s) - mesenchymal stem cell , pathology , giant cell , ultrastructure , soft tissue , medicine , peripheral blood mononuclear cell , tumor cells , cell , sarcoma , biology , cancer research , biochemistry , genetics , in vitro
Four cases of malignant giant cell tumor of soft parts (MGCT) were studied ultrastructurally. Most of the cells in three cases were identified as undifferentiated mesenchymal cells and mononuclear monohistiocytic cells. The osteoclastlike cells seemed to arise from fusion of monohistiocytic cells. Immature fibroblastic cells, occasionally containing filaments with densities, were also present. They were scarce in three cases and predominant in the fourth. It was concluded that MGCT is a mesenchymal sarcoma with a bimorphic—monohistiocytic and fibroblastic—differentiation. MGCT is therefore considered a special variant of malignant fibrous histiocytoma. Cancer 40:244–253, 1977.