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Particle radiation therapy. Experimental basis and clinical application
Author(s) -
Parker Robert G.
Publication year - 1977
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197707)40:1+<481::aid-cncr2820400712>3.0.co;2-5
Subject(s) - cosmesis , medicine , radiation therapy , proton therapy , medical physics , neutron , particle therapy , nuclear medicine , radiology , surgery , nuclear physics , physics
Conventional radiation therapy can eradicate cancers within tissues of their origin and regional spread with conservation of anatomic structure, thus preserving function and cosmesis. New treatment methods may improve the therapeutic ratio either by increasing the frequency of tumor control or lessening the treatment‐related morbidity, or both. There are several physical and biological reasons why particle radiation therapy may increase tumor cell killing without increasing normal tissue sequelae. After preliminary basic research, clinical trials of fast neutron and proton teletherapy were started. Over 700 patients were treated with fast neutron beams in 3 U.S. research programs. These studies will be extended to include negative pi mesons and heavy particles. Cancer 40:481–483, 1977.