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Role of bacterial overgrowth in the malabsorption syndrome of primary small intestinal lymphoma in Iran
Author(s) -
Russell R. M.,
Abadi P.,
IsmailBeigi F.
Publication year - 1977
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197706)39:6<2579::aid-cncr2820390641>3.0.co;2-j
Subject(s) - steatorrhea , malabsorption , medicine , gastroenterology , bacterial overgrowth , lymphoma , antibiotics , intrinsic factor , breath test , tetracycline , vitamin b12 , microbiology and biotechnology , helicobacter pylori , biology
Malabsorption studies were performed on five Iranian patients with primary small intestinal lymphoma. The effect of oral tetracycline (1.0 g daily) was also studied in three of the above subjects. The results of breath tests (utilizing glycine‐1‐ 14 C‐cholic acid) were abnormal in all five subjects before the antibiotic treatment. Oral tetracycline had a striking effect towards normalizing the results of breath tests. Schilling tests (with intrinsic factor) improve in two patients and steatorrhea improved in all and there was significant weight gain. The antibiotic had no apparent effect on D‐xylose or folate absorption tests. It is concluded that bacterial overgrowth in the small intestinal lumen is an important contributory factor to the malabsorption syndrome of this disease.