Premium
Isolation and characterization of a neuroblastoma cell line from peripheral blood in a patient with disseminated disease
Author(s) -
Gerson J. M.,
Schlesinger H. R.,
Sereni P.,
Moorhead P. S.,
Hummeler K.
Publication year - 1977
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197706)39:6<2508::aid-cncr2820390630>3.0.co;2-x
Subject(s) - medicine , neuroblast , peripheral blood , lymphoblast , neuroblastoma , pathology , cell culture , disease , isolation (microbiology) , cell , peripheral , immunology , biology , bioinformatics , microbiology and biotechnology , genetics , neurogenesis
Circulation in the blood stream of neuroblastoma cells was confirmed by establishment of a cell line from the peripheral blood of a child with disseminated disease. The morphologic, enzymatic, and chromosomal pattern of this cell line was similar to a cell line established from the primary tumor on a previous occasion. The peripheral blood smear did not demonstrate tumor cells but increased numbers of atypical monocytes; lymphoblasts were evident, which may have been unrecognized neuroblasts.