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Asynchronous development of two monoclonal proteins (igm λ and γ 1 chains) in a patient with abdominal lymphoma
Author(s) -
Virella G.,
Monteiro J. M. N.,
LopesVirella Maria F.,
Soares A. Ducla,
Fudenberg H. Hugh
Publication year - 1977
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197705)39:5<2247::aid-cncr2820390543>3.0.co;2-1
Subject(s) - medicine , lymphoma , monoclonal , monoclonal antibody , pathology , antibody , immunology
An IgM paraprotein was detected in a patient with abdominal lymphoma. Due to some doubts about the malignant nature of the situation, no cytostatic drugs were administered. When seen two years later the patient had considerably deteriorated in clinical status, with evidence of extra‐abdominal involvement. At this time he presented a second paraprotein of low of molecular weight (74,000 to 80,000), consisting of two covalently linked γ1‐chain fragments.