Premium
Plasma prostaglandins in hypercalcemic patients with neoplastic disease
Author(s) -
Demers L. M.,
Allegra J. C.,
Harvey H. A.,
Lipton A.,
Luderer J. R.,
Mortel R.,
Brenner D. E.
Publication year - 1977
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197704)39:4<1559::aid-cncr2820390430>3.0.co;2-3
Subject(s) - medicine , malignancy , endocrinology , prostaglandin , disease
Peripheral plasma prostaglandin E (PGE) determinations were performed on a series of 79 patients with solid tumor neoplasms and correlated with their serum calcium levels. Fourteen patients were hypercalcemic and 11 of these had significant elevations in circulating plasma PGE. Ten of the hypercalcemic group had extensive metastases to bone. These findings support the recently developed hypothesis that prostaglandins are causally related to the genesis of hypercalcemia in malignancy.