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Results of a randomized clinical trial of preoperative irradiation versus postoperative in treatment of tumors of the hypopharynx
Author(s) -
Vandenbrouck C.,
Sancho H.,
Le Fur R.,
Richard J. M.,
Cachin Y.
Publication year - 1977
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197704)39:4<1445::aid-cncr2820390415>3.0.co;2-6
Subject(s) - medicine , radiation therapy , randomized controlled trial , surgery , survival rate , overall survival , clinical trial
Preoperative radiotherapy vs postoperative radiotherapy in the management of patients with primary tumors of the hypopharynx was evaluated by a prospective, randomized clinical trial. A statistically significant difference (p < 1%) existed in favor of postoperative radiotherapy relative to survival rates, complications, and quality of survival. The postoperative radiotherapy group showed a 56% 5‐year survival rate compared to 20% in the preoperative radiotherapy group. An analysis of the results is discussed.