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Hypocalcemia with hypoparathyroidism and renal tubular dysfunction associated with aminoglycoside therapy
Author(s) -
Keating M. J.,
Sethi M. R.,
Bodey G. P.,
Samaan N. A.
Publication year - 1977
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197704)39:4<1410::aid-cncr2820390409>3.0.co;2-d
Subject(s) - medicine , hypomagnesemia , aminoglycoside , hypoparathyroidism , tobramycin , endocrinology , hypophosphatemia , hypokalemia , hypouricemia , calcitonin , hypocalcaemia , uric acid , gastroenterology , gentamicin , antibiotics , calcium , magnesium , materials science , biology , microbiology and biotechnology , metallurgy
Seventeen patients with malignant disease developed a complex metabolic syndrome of 2–8 weeks' duration characterized by hypocalcemia, hypomagne‐semia and hypokalemia following administration of the aminoglycoside group of antibiotics. Gentamicin, Tobramycin, Amikacin, and Sisomicin were all involved. Other features noted were hypoalbuminemia, hypophosphatemia, and hypouricemia. Low immunoreactive parathyroid hormone (i‐PTH) levels in the presence of hypocalcemia and absence of hyperplastic changes in the parathyroid gland examined at postmortem confirmed a diagnosis of hypoparathyroidism. Immunoreactive calcitonin levels (i‐CT) were not elevated. Renal tubular wasting of potassium and magnesium was documented in six patients and excessive urinary loss of sodium, phosphate, and uric acid was noticed. Twelve patients died before recovering from the metabolic stress and five patients developed progressive renal impairment. A possible potentiating action of chemotherapeutic agents, especially Adriamycin, is suggested.