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A minute hepato cellular carcinoma found in a liver with clonorchis sinensis infection. Report of two cases
Author(s) -
Nakashima Toshiro,
Sakamoto Kazuyoshi,
Okuda Kunio
Publication year - 1977
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197703)39:3<1306::aid-cncr2820390343>3.0.co;2-k
Subject(s) - clonorchis sinensis , clonorchiasis , hepatocellular carcinoma , medicine , cirrhosis , nodule (geology) , pathology , anaplasia , opisthorchis , metastasis , carcinoma , gastroenterology , liver fluke , cancer , biology , immunology , helminths , paleontology
Two cases of minute hepatocellular carcinoma (HCC) found in a liver infested with Clonorchis sinensis are described. One had mild infestation with hepatic changes suggestive of posthepatitic cirrhosis, and the other heavy infestation exhibiting secondary biliary cirrhosis with dilated intrahepatic bile ducts and periductal fibrosis. None had evidence of hepatitis B infection. The tumor nodule was solitary, measuring 5 × 7 mm and 10 × 11 mm, respectively, and the cells were differentiated to be classified as Grade I of Edmondson‐Steiner's scale of anaplasia. It is not clear whether or not clonorchiasis was etiologically related to HCC, but it was of interest that in both cases the tumor nodule was very small representing the primary lesion without metastasis.