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Acute myelomonocytic leukemia in a patient with macroglobulinemia and malignant lymphoma
Author(s) -
Ligorsky Robert D.,
Axelrod Arnold R.,
Mandell Gerald H.,
Palutke Margarita,
Prasad Ananda S.
Publication year - 1977
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197703)39:3<1156::aid-cncr2820390321>3.0.co;2-t
Subject(s) - acute myelomonocytic leukemia , macroglobulinemia , medicine , leukemia , lymphoma , pathology , chronic myelomonocytic leukemia , acute leukemia , waldenstrom macroglobulinemia , immunology , cancer research , multiple myeloma , bone marrow , myelodysplastic syndromes
Acute myelomonocytic leukemia occurred in a 69‐year‐old man with malignant lymphoma and macroglobulinemia. Fluorescent staining demonstrated the macroglobulin in plasma and leukemic cells. Plasma cells seemed to be producing paraproteins, while leukemic cells appeared to be engulfing them as seen with transmission electron microscopy. The sequence of events ruled out the possibility that myelomonocytic leukemia developed following the use of cytotoxic drugs. The case presented in this report is a rare example of malignant lymphoma, macroglobulinemia, and acute myelomonocytic leukemia occurring in the same patient.