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Metaplastic squamous cell carcinoma of bronchus simulating giant cell tumor of bone
Author(s) -
Oyasu Ryoichi,
Battifora Hector A.,
Buckingham William B.,
Hidvegi Denise
Publication year - 1977
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197703)39:3<1119::aid-cncr2820390317>3.0.co;2-7
Subject(s) - histogenesis , pathology , giant cell , medicine , bronchus , carcinoma , mesenchymal stem cell , pneumonectomy , biopsy , large cell , adenocarcinoma , lung , respiratory disease , lung cancer , cancer , immunohistochemistry
A 57‐year‐old man underwent a right pneumonectomy for a bronchogenic carcinoma following bronchoscopy and bronchial biopsy. The tumor was a polypoid mass arising from the lower lobe bronchus. Microscopically it was characterized by mononuclear cells mixed with randomly distributed multinucleated giant cells similar to those seen in giant‐cell tumor of bone. Also found were portions showing typical squamous cell and spindle cell carcinoma. Based on the light and electron microscopic findings, we suggest that the current case represents a metaplastic squamous carcinoma showing mesenchymal cell differentiation. A hypothesis on the histogenesis of pleomorphic carcinomas was presented. The problems of histological diagnosis generated by such a tumor should be emphasized.