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Stages I—III Hodgkin's disease in children. Results of staging and treatment
Author(s) -
Botnick Leslie E.,
Goodman Robert,
Jaffe Norman,
Filler Robert,
Cassady J. Robert
Publication year - 1977
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197702)39:2<599::aid-cncr2820390234>3.0.co;2-0
Subject(s) - medicine , disease , splenectomy , laparotomy , pelvis , stage (stratigraphy) , surgery , nodular sclerosis , lymphoma , spleen , hodgkin lymphoma , paleontology , biology
Fifty‐two children with clinical stages I‐III Hodgkin's disease were evaluated for disease extent between April 1969 and March 1975. All underwent laparotomy and splenectomy. Two patients with liver involvement were excluded. Thirty of 31 patients with pathologically staged IA‐IIA disease have been in continuous complete remission after mantle and para‐aortic irradiation. There have been no extensions into the untreated pelvis. Fourteen of 15 patients with pathologic stages IIB and IIIB disease show no evidence of relapse after TNI and MOPP. Three of four patients with stage IIIA disease developed nodal relapse after irradiation; all are alive without evidence of disease after re‐irradiation (3) and MOPP (2). Thus 45 of 50 patients (90%) have remained continuously free of disease after completion of the planned treatment, and overall 49 of 50 (98%) are alive without evidence of disease. Such results justify continuation of our staging and treatment philosophy in children with Hodgkin's disease.