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The effects of therapeutic irradiation on lymphocytes and immunity
Author(s) -
Order Stanley E.
Publication year - 1977
Publication title -
cancer
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.052
H-Index - 304
eISSN - 1097-0142
pISSN - 0008-543X
DOI - 10.1002/1097-0142(197702)39:2+<737::aid-cncr2820390708>3.0.co;2-m
Subject(s) - medicine , immune system , immunity , disease , depression (economics) , cancer , immune dysfunction , immunology , oncology , economics , macroeconomics
The lymphocytotoxic effect of therapeutic irradiation may lead to immune depression. The significance of such effects is yet to be determined in many malignancies, especially in light of the persistant immune depression in many “cured” patients. The present review examines the effects of age, type of cancer, and stage of disease as well as the results of immune parameters following radiation therapy. Factors to be considered in both the analysis of present day data and in future studies are also reviewed.